Kev sib hloov ntawm cov ntsia hlau, Muaj ob tsev neeg ntawm ntxaib ntsia hlau extruders, xaiv cov khoom tseem ceeb hauv kev tsim cov khoom lag luam zoo ...
Kev sib hloov ntawm cov ntsia hlau tsim kev sib faib thiab dispersive sib xyaw.Distributive mixing maximizes division thiab recombination ntawm cov ntaub ntawv thaum txo lub zog input los ntawm kev sib xyaw nrog tsawg extensional thiab planar-shear teebmeem.Qhov no sib xyaw ua ke cov ntaub ntawv tab sis tsis txo qis cov khoom tawg yooj yim particle loj thiab yields tsawg thermal thiab shear degradation ntawm cov ntaub ntawv rhiab heev.
Dispersive mixing siv extensional thiab planar shear teb los rhuav tshem cov ntaub ntawv dispersed mus rau me me, hom phiaj siv lub zog ntawm los yog me ntsis siab tshaj qhov pib theem uas yuav tsum tau mus ua txhaum lawv.
Kev siv cov ntsiab lus sib txawv tso cai rau lub ntxaib ntsia hlau extruder ua ob qho tib si qhov loj me me txo thiab sib tov kom cov APIs tuaj yeem muab tso rau hauv cov polymer hauv daim ntawv dispersed lossis, yog tias API solubility hauv polymer yog siab txaus, hauv daim ntawv yaj.Txij li thaum lub extrudate txias sai heev ntawm kev tawm ntawm extruder, txhua API uas yog yaj nyob rau hauv lub polymer ntawm qhov sib tov kub yuav tsis muaj peev xwm recrystallize rau txias, ua rau supersaturated solid solutions.Nyob rau hauv xws li kev ruaj ntseg ntawm cov khoom yuav tsum tau ua raws li zoo raws li recrystallization ntawm API nyob rau lub sij hawm ntev-scales yog ua tau, tshwj xeeb tshaj yog nyob rau hauv siab cia kub thiab siab API loadings, thiab tej zaum yuav cuam tshuam lub txee lub neej ntawm cov khoom zaum kawg.
Muaj ob tsev neeg ntawm ntxaib ntsia hlau extruders: high-speed zog input (HSEI) ntxaib-ntsia hlau extruders, uas feem ntau yog siv rau compounding, reactive ua thiab/los yog devolatilization, thiab low-speed lig fusion (LSLF) twin-ntsia hlau extruders, tsim los sib tov ntawm qis shear thiab twj tso kua mis ntawm uniform pressures.Screws tej zaum yuav co-rotating (self-wiping), los yog counter rotating (calendar gap), nrog rau feem ntau extruders siv rau nws yog co-rotating.
Ntau hom kev tawm tuag yog siv los tsim cov extrudate rau qhov xav tau profile.Cov tuag no suav nrog cov ntawv thiab zaj duab xis tuag siv rau hauv daim ntawv thov transdermal zaj duab xis, strand tuag siv rau kev kho mob tubing thiab qee cov khoom siv tshuaj tua kab mob, cov duab tuag siv hauv tshuab moulding, thiab co-extrusion tuag siv hauv cov khoom siv hauv reservoir tsim.Cov khoom siv sib txawv hauv qab no kuj siv rau hauv cov txheej txheem ua tiav, suav nrog cov dej da dej thiab cua tshuab cua txias, conveyor siv rau kev txav cov khoom extruded los ntawm qhov tuag mus rau qhov kawg ntawm kab, strand-cutters rau txiav cov extrudate rau hauv tubing los yog rods, thiab spooler rau extrudate sau.Pelletizers yog siv los txiav cov extrudate rau hauv me me rau cov tshuaj capsule ncaj qha filling thiab nyob rau hauv cov ntaub ntawv ntawm ib co pab kiag li lawm rau txhaj tshuaj molding los tsim cov khoom kawg.
Raws li nrog rau txhua daim ntawv ntau npaum, kev xaiv cov khoom siv tseem ceeb hauv kev tsim cov khoom lag luam zoo.Rau feem ntau cov ntawv thov, cov khoom siv polymer yuav tsum yog cov thermoplastic, ruaj khov ntawm qhov kub thiab txias siv hauv cov txheej txheem, thiab cov tshuaj sib xyaw nrog API thaum lub sij hawm extrusion.Rau cov ntaub ntawv ntawm qhov ncauj ntau npaum li cas, dej soluble polymers feem ntau yog xaiv los ntawm cov polymers uas twb tau siv hauv cov khoom siv tshuaj xws li poly (ethylene glycol) thiab poly (vinylpyrrolidinone).Nrog rau kev txaus siab ntxiv hauv kev siv HME rau cov khoom siv tshuaj, cov khoom lag luam polymer loj tseem tab tom pib muab cov polymers tshwj xeeb tsim rau kev siv tshuaj.Rau cov cuab yeej siv tshuaj, cov polymers feem ntau yog dej-insoluble, thiab feem ntau ntawm cov khoom siv hauv kev tsim kho siv ethylene vinyl acetate copolymers (EVAs) lossis polyurethanes.
HME tso cai rau API kom sib xyaw nrog cov polymer nyob rau hauv qhov tsawg kawg nkaus ntawm shear thiab thermal stresses thiab li no nrog tsim cov txheej txheem tsawg tsawg-txog API degradants.Cov tshuaj tiv thaiv antioxidant feem ntau suav nrog hauv kev tsim, thiab lub sijhawm nyob luv luv hauv lub thoob (feem ntau ntawm qhov kev txiav txim ntawm feeb) kuj pab txo qis thermal degradation tshwj xeeb tshaj yog piv rau batch mixing thiab lwm yam txheej txheem sib xyaw.
Ib lub tswv yim los tswj cov tshuaj elution kinetics los ntawm cov khoom siv xws li intravaginal rings suav nrog kev txuas ntxiv ntawm cov txheej txheem extrusion yooj yim.Ib txhij extrusion ntawm cov tshuaj-loaded core strand nrog ib tug tso-tswj polymer sheath uas encapsulates cov tub ntxhais nyob rau hauv ib tug tib co-extrusion txheej txheem ua ib tug ob-txheej core-sheath strand.Ib lub taub hau extrusion tshwj xeeb yog pub los ntawm ob qhov perpendicular extruders - ib qho muab cov ntsiab lus tseem ceeb, lwm qhov muab cov khoom siv hauv cov ntaub.Cov tub ntxhais-sheath strand yog txiav thiab qhov xaus txuas nrog ua cov cuab yeej kawg.
HME muab cov khoom tsim tawm ntawm cov khoom siv kho mob, rhuav tshem cov ntaub ntawv ntawm qhov ncauj thiab cov khoom siv tshuaj eluting nrog cov txheej txheem kev xaiv uas ua kom API sib xyaw nrog polymer, thaum txo qis API degradation, thiab txawm qhib qhov rooj rau cov khoom uas tsis tuaj yeem npaj los ntawm lwm txoj kev.
Post lub sij hawm: Aug-01-2017