Hom Kub Melt Extrusion

Kub-melt extrusion (HME) yog txheej txheem tsim uas tau siv txij li thaum xyoo 1930s, feem ntau hauv kev tsim cov yas ...

Muaj ob hom extruders: ib leeg thiab ntxaib ntsia hlau extruders.Ib qho ntsia hlau extruders feem ntau yog siv rau melting thiab conveying polymers rau extrude lawv mus rau hauv cov duab nruam, whereas ntxaib ntsia hlau extruders yog siv rau melt-sib xyaw polymers nrog cov ntaub ntawv ntxiv (pigments, fillers, reinforcers, thiab APIs), thiab rau devolatilization.Hauv kev tsim cov tshuaj formulations, uas yuav tsum tau homo-geneous thiab zoo sib xws ntawm ntau formulation cov khoom xyaw, ib tug ntxaib ntsia hlau extruder yog nyiam vim hais tias kev sib hloov ntawm inter-meshing screws muab zoo sib tov los tsim ib tug homogeneous khoom uas muaj finely dispersed API hais, los yog ib tug solid-solution ntawm API nyob rau hauv polymer.Qhov no tuaj yeem txhim kho tus nqi tawg thiab bioavail-muaj peev xwm ntawm cov dej tsis zoo-soluble API formulations.Uniformly distrib-uted API tseem yog qhov yuav tsum tau ua ua ntej rau kev tsim cov tshuaj-eluting li nrog intra- thiab inter-batch reproducibility ntawm tshuaj-tso ki-netics.

Melting yog ua tiav los ntawm fric-tional cua sov nyob rau hauv lub chim, thiab rau ntxaib-ntsia hlau extruders, raws li cov ntaub ntawv undergo shearing ntawm lub rotating screws thiab nruab nrab ntawm lub screws thiab phab ntsa ntawm lub chim thaum lawv raug xa mus.Lub thoob kuj tau rhuab nrog cov cua sov tso rau ntawm lub thoob, los yog txias nrog dej.Lub thoob qhov ntsuas kub feem ntau yog opti-mized kom lub viscosity ntawm cov yaj yog tsawg txaus kom cia con-veying down lub chim thiab sib tov kom zoo, thaum ua kom tempera-tures tsawg txaus kom tsis txhob thermal degradation ntawm cov ntaub ntawv.

Cov ntsia hlau ntawm ntxaib ntsia hlau extruder feem ntau yog muab ntau hom kev sib xyaw thiab kev xa khoom ntawm ntau thaj chaw hauv lub thoob.Thaum lub sij hawm tsim khoom, modular screws nrog ntau yam ele-ments haum rau ib tug ntau ncej, tso cai rau cov tailoring thiab optimization ntawm cov ntsia hlau tsim rau txhua yam khoom.Cov ntu ntawm cov ntsia hlau tuaj yeem tsim los ua kom txo qhov loj me me, sib xyaw thiab xa cov haujlwm.Qhov ntev ntawm cov ntsia hlau nyob rau hauv kev sib raug zoo nrog lub thoob txoj kab uas hla (L / D piv) yog xaiv los optimize lub degree ntawm kev sib xyaw thiab cov naj npawb ntawm cov cheeb tsam yuav tsum tau ua kom tiav cov khoom kawg char-acteristics.Ib qho piv txwv ntawm tag nrho modular ntsia hlau.Ib qho kev tsim cov ntsia hlau ib leeg tuaj yeem ua rau tib tus qauv tsim raws li kev txhim kho screws, tab sis yooj yim dua los ntxuav rau cGMP ua raws.